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Ming Liu, Bingtai Lu, Yue Li, Shuofeng Yuan, Zhen Zhuang, Guangyu Li, Dong Wang, Liuheyi Ma, Jianheng Zhu, Jinglu Zhao, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Kenn Ka-Heng Chik, Zhiyao Zhao, Huifang Xian, Jingxian Zhao, Jincun Zhao, Jasper Fuk-Woo Chan & Yuxia Zhan

08 Oct 2023
P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation

Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-023-01631-0

Jie-Feng Yang, Xudong Xing, Li Luo, Xin-Wei Zhou, Jian-Xiong Feng, Kang-Bo Huang, Huashan Liu, Shanzhao Jin, Yi-Na Liu, Shi-Hui Zhang, Yi-Hui Pan, Bing Yu, Jin-Yu Yang, Yu-Lu Cao, Yun Cao, Cliff Y. Yang, Yuan Wang, Yuxia Zhang, Jiang Li , Xiaojun Xia, Tiebang Kang , Rui-Hua Xu, Ping Lan, Jun-Hang Luo, Hui Han, Fan Bai, Song Gao

21 Sep 2023
Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

Science Immunology

DOI: https://doi.org/10.1126/sciimmunol.abq2424

Meng Lin, Huifang Xian, Zhanghua Chen, Shang Wang, Ming Liu, Weiwei Liang, Qin Tang, Yao Liu, Wanming Huang, Di Che, Caiqin Guo, Elina Idiiatullina, Rongli Fang, Mahmoud AL-Azab, Jingjie Chang, Rongze Wang, Xiaojun Li, Xiaoyu Zuo, Yan Zhang, Jincun Zhao, Yaping Tang, Shouheng Jin, Zhengjie He, Du Feng, Liwei Lu, Kang Zhang, Yan Wu, Fan Bai, Andrew M. Lew, Jun Cui, Yuzhang Wu, Xiaoqiong Gu, Yuxia Zhang

04 Sep 2023
MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease

Nature Cardiovascular Research

DOI: https://www.nature.com/articles/s44161-023-00314-x

Shengbo Zhang, Jai Rautela, Naiara G. Bediaga, Tatiana B. Kolesnik, Yue You, Junli Nie, Laura F. Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L. Nutt, Andrew M. Lew, Nicholas D. Huntington, Sandra E. Nicholson, Michaël Chopin, Yifan Zhan

19 Jan 2023
CIS controls the functional polarization of GM-CSF-derived macrophages

Cellular & Molecular Immunology

DOI: https://doi.org/10.1038/s41423-022-00957-z

Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, James E Vince

17 Jan 2023
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency

The EMBO Journal

DOI: https://doi.org/10.15252/embj.2021110468

Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah Coughlan, Pedro L Baldoni, Nicolas Jacquelot, Wang HJ Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P Wicks, Warren S Alexander, Leonard C Harrison, Andrew M Lew, Gordon K Smyth, Stephen L Nutt, Michaël Chopin

17 Sep 2021
Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis

Science Immunology

DOI: https://doi.org/10.1126/sciimmunol.abf7268

Xuangjie Guo, Yiping Xu, Wei Luo, Rongli Fang, Li Cai, Ping Wang, Yuxia Zhang, Zhe Wen, Yanhui Xu

16 Jul 2021
Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

BMC pediatrics

DOI: https://doi.org/10.1186/s12887-021-02794-x

Huifang Xian, Wanming Huang, Tingzhe Sun, Shuai Yang, Chuanxia Zhang, Jun Wang, Yuxia Zhang, Jun Cui

30 Apr 2021
Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression

Science Bulletin

DOI: https://doi.org/10.1016/j.scib.2020.11.003

Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak, Liwei Lu

26 Mar 2021
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection

Nature Communications

DOI: https://doi.org/10.1038/s41467-021-22242-9

Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L Masters, Andrew M Lew, Sitang Gong, Fan Bai, Jing Yang, Pamela Pui-Wah Lee, Wanling Yang, Yan Zhang, Yu-Lung Lau, Lanlan Geng, Yuxia Zhang, Jun Cui

01 Jan 2021
Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development

Journal of Allergy and Clinical Immunology

DOI: https://doi.org/10.1016/j.jaci.2020.09.003

Jun Wang, Yanhui Xu, Zhanghua Chen, Jiankun Liang, Zefeng Lin, Huiying Liang, Yiping Xu, Qi Wu, Xuanjie Guo, Junli Nie, Bingtai Lu, Bing Huang, Huifang Xian, Xiaohui Wang, Qiang Wu, Jixiao Zeng, Chengwei Chai, Meixue Zhang, Yuzhen Lin, Li Zhang, Shanmeizi Zhao, Yanlu Tong, Liang Zeng, Xiaoqiong Gu, Zhuang-gui Chen, Shuhong Yi, Tong Zhang, David Delfouneso, Yan Zhang, Stephen L Nutt, Andrew M Lew, Liwei Lu, Fan Bai, Huimin Xia, Zhe Wen, Yuxia Zhang

23 Dec 2020
Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia

Cell

DOI: https://doi.org/10.1016/j.cell.2020.10.048

Zhe Li, Xin Li, Yi-You Huang, Yaoxing Wu, Runduo Liu, Lingli Zhou, Yuxi Lin, Deyan Wu, Lei Zhang, Hao Liu, Ximing Xu, Kunqian Yu, Yuxia Zhang, Jun Cui, Chang-Guo Zhan, Xin Wang, Hai-Bin Luo

03 Nov 2020
Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.2010470117

Ji-Yuan Zhang, Xiang-Ming Wang, Xudong Xing, Zhe Xu, Chao Zhang, Jin-Wen Song, Xing Fan, Peng Xia, Jun-Liang Fu, Si-Yu Wang, Ruo-Nan Xu, Xiao-Peng Dai, Lei Shi, Lei Huang, Tian-Jun Jiang, Ming Shi, Yuxia Zhang, Alimuddin Zumla, Markus Maeurer, Fan Bai, Fu-Sheng Wang

12 Aug 2020
Single-cell landscape of immunological responses in patients with COVID-19

Nature Immunology

DOI: https://doi.org/10.1038/s41590-020-0762-x

Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M Lew, Jun Cui, Rongli Fang, Hui Huang, Jincun Zhao, Xuechuan Hong, Yuxia Zhang, Fuling Zhou, Hai-Bin Luo

01 Jul 2020
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

Acta Pharmaceutica Sinica B

DOI: https://doi.org/10.1016/j.apsb.2020.04.008

Shanmeizi Zhao, Meng Lin, Yuxia Zhang

01 Apr 2020
DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability.

Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology

DOI: https://europepmc.org/article/med/32519665

Ming Liu, Bingtai Lu, Ping Zeng, Bing Huang, Yanhui Xu, Hanquan Liang, Diyuan Yang, Sida Yang, Hai-bin Luo, Andrew M Lew, Seth L Masters, Lanlan Geng, Huasong Zeng, Yuxia Zhang

27 Mar 2020
Compound Heterozygous Mutations of IL12RB1 in a Patient with Selective Defects in Th17 Differentiation

Journal of Clinical Immunology

DOI: https://doi.org/10.1007/s10875-020-00771-0

Huifang Xian, Shuai Yang, Shouheng Jin, Yuxia Zhang, Jun Cui

03 Mar 2020
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

Autophagy

DOI: https://doi.org/10.1080/15548627.2019.1615303

Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang, Yifan Zhan, Gen Lu

28 Feb 2020
IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

Mucosal Immunology

DOI: https://doi.org/10.1038/s41385-020-0273-y

Fu-Sheng Wang, Ji-Yuan Zhang, Xiangming Wang, Xudong Xing, Zhe Xu, Chao Zhang, Jin-Wen Song, Xing Fan, Peng Xia, Jun-Liang Fu, Si-Yu Wang, Ruo-Nan Xu, Xiao-Peng Dai, Lei Shi, Lei Huang, Tian-Jun Jiang, Ming Shi, Yuxia Zhang, Alimuddin Zumla, Markus Maeurer, Fan Bai

01 Jan 2020
Single-cell landscape of immunological responses in COVID-19 patients

bioRxiv

DOI: https://doi.org/10.1101/2020.07.23.217703

Bing Huang, Zhanghua Chen, Lanlan Geng, Jun Wang, Huiying Liang, Yujie Cao, Huan Chen, Wanming Huang, Meiling Su, Hanqing Wang, Yanhui Xu, Yukun Liu, Bingtai Lu, Huifang Xian, Huiwen Li, Huilin Li, Lu Ren, Jing Xie, Liping Ye, Hongli Wang, Junhong Zhao, Peiyu Chen, Li Zhang, Shanmeizi Zhao, Ting Zhang, Banglao Xu, Di Che, Wenyue Si, Xiaoqiong Gu, Liang Zeng, Yong Wang, Dingyou Li, Yifan Zhan, David Delfouneso, Andrew M Lew, Jun Cui, Wai Ho Tang, Yan Zhang, Sitang Gong, Fan Bai, Min Yang, Yuxia Zhang

14 Nov 2019
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

Cell

DOI: https://doi.org/10.1016/j.cell.2019.10.027

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

11 Dec 2018
CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells

Cellular & Molecular Immunology

DOI: https://doi.org/10.1038/s41423-018-0187-8

Fiona Moghaddas, Ping Zeng, Yuxia Zhang, Heike Schützle, Sebastian Brenner, Sigrun R Hofmann, Reinhard Berner, Yuanbo Zhao, Bingtai Lu, Xiaoyun Chen, Li Zhang, Suyun Cheng, Stefan Winkler, Kai Lehmberg, Scott W Canna, Peter E Czabotar, Ian P Wicks, Dominic De Nardo, Christian M Hedrich, Huasong Zeng, Seth L Masters

01 Dec 2018
Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

Journal of Allergy and Clinical Immunology

DOI: https://doi.org/10.1016/j.jaci.2018.04.033

Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison

25 Apr 2018
Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner

Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.00879

Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O’Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison

15 Dec 2017
CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation

Cell Death & Differentiation

DOI: https://doi.org/10.1038/cdd.2017.173

Yifan Zhan, Emma M Carrington, Yuxia Zhang, Susanne Heinzel, Andrew M Lew

13 Dec 2017
Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?

Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.01809

Leonard Charles Harrison, Maryam Rashidi, Yuxia Zhang

10 Oct 2017
Method of treating sepsis by administering a soluble CD52 glycoprotein

DOI:

Yuxia Zhang, Bing Huang

14 Sep 2017
The Development and Diversity of ILCs, NK Cells and Their Relevance in Health and Diseases

Regulation of Inflammatory Signaling in Health and Disease

DOI: https://doi.org/10.1007/978-981-10-5987-2_11

Esther Bandala Sanchez, James Dromey, Leonard Charles Harrison, Yuxia Zhang

07 Mar 2017
Soluble Mediator

DOI:

Yuxia Zhang, Zhi-Ping Feng, Gaetano Naselli, Fiona Bell, James Wettenhall, Priscilla Auyeung, Justine A Ellis, Anne-Louise Ponsonby, Terence P Speed, Mark MW Chong, Leonard C Harrison

01 Apr 2016
MicroRNAs in CD4+ T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes

DOI: https://doi.org/10.1016/j.jaut.2015.12.006

Yuxia Zhang, Fiona Collier, Gaetano Naselli, Richard Saffery, Mimi LK Tang, Katrina J Allen, Anne-Louise Ponsonby, Leonard C Harrison, Peter Vuillermin, BIS Investigator Group‡

13 Jan 2016
Cord blood monocyte–derived inflammatory cytokines suppress IL-2 and induce nonclassic “TH2-type” immunity associated with development of food allergy

Science Translational Medicine

DOI: https://doi.org/10.1126/scitranslmed.aad4322

Leonard Charles Harrison, Maryam Rashidi, Yuxia Zhang

17 Sep 2015
Soluble Mediator

DOI:

Noor HA Suaini, Yuxia Zhang, Peter J Vuillermin, Katrina J Allen, Leonard C Harrison

27 Jul 2015
Immune Modulation by Vitamin D and Its Relevance to Food Allergy

Multidisciplinary Digital Publishing Institute

DOI: https://doi.org/10.3390/nu7085271

Yuxia Zhang, Sarah Kinkel, Jovana Maksimovic, Esther Bandala-Sanchez, Maria C Tanzer, Gaetano Naselli, Jian-Guo Zhang, Yifan Zhan, Andrew M Lew, John Silke, Alicia Oshlack, Marnie E Blewitt, Leonard C Harrison

31 Jul 2014
The polycomb repressive complex 2 governs life and death of peripheral T cells

Blood, The Journal of the American Society of Hematology

DOI: https://doi.org/10.1182/blood-2013-12-544106

Zhijun Jiao, Sammy Bedoui, Jamie L Brady, Anne Walter, Michael Chopin, Emma M Carrington, Robyn M Sutherland, Stephen L Nutt, Yuxia Zhang, Hyun-Ja Ko, Li Wu, Andrew M Lew, Yifan Zhan

17 Mar 2014
The Closely Related CD103+ Dendritic Cells (DCs) and Lymphoid-Resident CD8+ DCs Differ in Their Inflammatory Functions

Public Library of Science

DOI: https://doi.org/10.1371/journal.pone.0091126

Yuxia Zhang, Jovana Maksimovic, Gaetano Naselli, Junyan Qian, Michael Chopin, Marnie E Blewitt, Alicia Oshlack, Leonard C Harrison

17 Oct 2013
Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

Blood, The Journal of the American Society of Hematology

DOI: https://doi.org/10.1182/blood-2013-02-481788

Leonard C Harrison, John M Wentworth, Yuxia Zhang, Esther Bandala-Sanchez, Ralph M Böhmer, Alana M Neale, Natalie L Stone, Gaetano Naselli, Julian J Bosco, Priscilla Auyeung, Maryam Rashidi, Petra Augstein, Grant Morahan

01 Oct 2013
Antigen-Based Vaccination and Prevention of Type 1 Diabetes

Current Diabetes Reports

DOI: https://doi.org/10.1007/s11892-013-0415-7

Yanlu Zan, Yuxia Zhang, Po Tien

07 Jun 2013
Hepatitis B virus e antigen induces activation of rat hepatic stellate cells

Biochemical and biophysical research communications

DOI: https://doi.org/10.1016/j.bbrc.2013.04.098

Esther Bandala-Sanchez, Yuxia Zhang, Simone Reinwald, James A Dromey, Bo-Han Lee, Junyan Qian, Ralph M Böhmer, Leonard C Harrison

19 May 2013
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

Nature immunology

DOI: https://doi.org/10.1038/ni.2610

Sanchez Esther Bandala, James Dromey, Leonard Charles Harrison, Yuxia Zhang, Maryam Rashidi

15 Nov 2012
Soluble mediator

DOI:

Yuxia Zhang, Esther Bandala-Sanchez, Leonard C Harrison

01 Aug 2012
Revisiting regulatory T cells in type 1 diabetes

Current Opinion in Endocrinology, Diabetes and Obesity

DOI: https://doi.org/10.1097/MED.0b013e328355a2d5

Yifan Zhan, Yuxia Zhang, Daniel Gray, Emma M Carrington, Philippe Bouillet, Hyun-Ja Ko, Lorraine O'Reilly, Ian P Wicks, Andreas Strasser, Andrew M Lew

15 Aug 2011
Defects in the Bcl-2–Regulated Apoptotic Pathway Lead to Preferential Increase of CD25lowFoxp3+ Anergic CD4+ T Cells

The Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1100027

Yuxia Zhang, Shu Li, Ming Shan, Xuwen Pan, Ke Zhuang, Lihua He, Keith Gould, Po Tien

18 Jan 2007
Hepatitis B virus core antigen epitopes presented by HLA-A2 single-chain trimers induce functional epitope-specific CD8+ T-cell responses in HLA-A2·1/Kb transgenic mice

Immunology

DOI: https://doi.org/10.1111/j.1365-2567.2007.02543.x

Yuxia Zhang, Yanlu Zan, Ming Shan, Changmei Liu, Ming Shi, Wei Li, Zhixin Zhang, Na Liu, Fusheng Wang, Weidong Zhong, Fulian Liao, George F Gao, Po Tien

02 Jun 2006
Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion

Biochemical and Biophysical Research Communications

DOI: https://doi.org/10.1016/j.bbrc.2006.03.171

Xiaoyan Gong, Xien Gui, Yuxia Zhang, Po Tien

01 Jan 2006
Screening for CD8 cytotoxic T lymphocytes specific for Gag of human immunodeficiency virus type 1 subtype B′ Henan isolate from China and identification of novel epitopes restricted by the HLA-A2 and HLA-A11 alleles

Journal of General Virology

DOI: https://doi.org/10.1099/vir.0.81335-0

Hong-Tao Li, Jia-Bin Yan, Jing Li, Ming-Hai Zhou, Xiao-Dong Zhu, Yu-Xia Zhang, Po Tien

21 May 2005
Enhancement of humoral immune responses to HBsAg by heat shock protein gp96 and its N-terminal fragment in mice

World Journal of Gastroenterology: WJG

DOI: https://doi.org/10.3748/wjg.v11.i19.2858

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